Award
National Institute of Allergy and Infectious Diseases 3R01AI175941-04S2
Defining correlates of protection from dengue illness in a long-term cohort study of multigenerational house-holds in Thailand
Recipient
Upstate Medical University
Award Amount
$149,854.00
Ceiling
$149,854.00
Awarded
July 15, 2026
Identifier
3R01AI175941-04S2
Research project studying immune correlates of protection from dengue illness using a long-term cohort in Thailand to support vaccine development and public health surveillance.
Description
This study will leverage an established and uniquely long-term family cohort study for DENV in Thailand to define how the early immune environment to DENV, as shaped by maternally-transferred DENV antibodies and the timing and features of early DENV and non-DENV flavivirus exposures, shapes an individual’s future antibody-mediated immune profiles to DENV and subsequent risks of dengue illness. The research aims to identify immune correlates of protection to improve vaccine and public health strategies.