Award
National Heart, Lung, and Blood Institute 1R03HL171446-01A1
Role of Aldehyde Dehydrogenase 2 in Resolution of Fibroproliferative ARDS
Recipient
University of Colorado Denver
Award Amount
$189,000.00
Ceiling
$189,000.00
Awarded
July 11, 2025
Identifier
1R03HL171446-01A1
NIH-funded research project investigating the role of ALDH2 enzyme in reducing lung fibrosis in ARDS through cell and animal models and human tissue studies, aiming to develop new therapies.
Description
This project aims to understand the role of the enzyme ALDH2 in the development and resolution of Fibroproliferative ARDS (FP-ARDS). The research will explore mechanisms by which ALDH2 inhibits lung fibrogenesis using cell culture models and genetically modified mice. The study will also test pharmacologic activation of ALDH2 in human lung tissue slices to evaluate potential therapeutic benefits.