Award
National Institute of Allergy and Infectious Diseases 5R01AI127469-09
Molecular and structural characterization of broadly neutralizing anti-HCV antibodies
Recipient
Johns Hopkins University
Award Amount
$804,923.00
Ceiling
$804,923.00
Awarded
January 22, 2026
Identifier
5R01AI127469-09
Johns Hopkins University received funding from the National Institute of Allergy and Infectious Diseases to study broadly neutralizing antibodies against hepatitis C virus, aiming to inform vaccine design through molecular and structural characterization of antibody interactions with viral proteins.
Description
This project aims to isolate and analyze a large set of E1E2-specific broadly neutralizing antibodies (bNAbs) from individuals with spontaneous clearance of HCV, to inform structure-based vaccine design. It involves molecular and structural characterization of interactions between HCV envelope proteins and monoclonal antibodies capable of blocking diverse HCV variants, facilitating rational vaccine design against HCV and potentially other highly variable human viruses.