Award
NIH Reporter #1R01GM159656-01A1
A novel role for LONP1 in connecting mitochondrial proteostasis with nuclear epigenetics
Recipient
Baylor College of Medicine, Houston, TX
Award Amount
$348,800.00
Ceiling
$348,800.00
Awarded
July 24, 2026
Identifier
1R01GM159656-01A1
Research project funded by NIGMS to study the role of mitochondrial enzyme LONP1 in regulating nuclear gene activity, with implications for stem cell regeneration, cancer progression, and potential novel therapies.
Description
This research investigates how a mitochondrial enzyme regulates gene activity in the nucleus through metabolic signals that affect cell health. By uncovering how this new pathway controls both stem cell regeneration and cancer progression, the findings may lead to novel therapies. Its clinical relevance spans age-related decline and malignancies such as multiple myeloma.