Award
National Institute of Allergy and Infectious Diseases 1R56AI192693-01
Discovery and development of novel HCMV inhibitors
Recipient
Medical College of Wisconsin, Milwaukee, WI
Award Amount
$762,983.00
Ceiling
$762,983.00
Awarded
August 27, 2025
Identifier
1R56AI192693-01
This award funds research to develop new inhibitors against human Cytomegalovirus (HCMV) by targeting the helicase-primase complex, aiming to overcome drug resistance and toxicity issues of current treatments.
Description
The project aims to develop novel inhibitors targeting the helicase-primase complex of HCMV. The goal is to confirm the H/P complex as a druggable target and identify small molecule inhibitors. The project involves virology, proteomics, structural biology, biophysics, biochemistry, and chemistry.