Award
NIH Reporter #1R21AG102223-01
Roles of Misfolded Protein Aggregates on Latent Reservoirs in SIV-infected, ART-treated Aged Rhesus Macaques
Recipient
University of Nebraska Medical Center, Omaha, NE
Award Amount
$422,125.00
Ceiling
$422,125.00
Awarded
May 19, 2026
Identifier
1R21AG102223-01
Research project studying the effects of aging-related amyloid accumulation on HIV reservoirs and Alzheimer's disease progression in aged, SIV-infected rhesus macaques under ART treatment.
Description
The project investigates how aging-related amyloid accumulation affects HIV reservoirs and how HIV infection and ART may accelerate Alzheimer’s disease (AD/ADRD). Using aged, SIV-infected, cART-treated rhesus macaques, the study explores the intersection of HIV, neurodegeneration, and aging. The research aims to understand the impact of amyloid fibril deposition on the reactivation and expansion of latent reservoirs in older people living with HIV, and how HIV influences the development of late-onset AD-ADRD.