Award
National Heart, Lung, and Blood Institute 1R01HL185877-01
Effects of chronic hypoxia on cerebral blood flow autoregulation in the newborn.
Recipient
Loma Linda University
Award Amount
$776,881.00
Ceiling
$776,881.00
Awarded
June 08, 2026
Identifier
1R01HL185877-01
Research project funded by NHLBI to study how chronic hypoxia affects cerebral blood flow regulation in newborns, focusing on TrpC6 ion channel and epigenetic factors, aiming to develop therapies to prevent brain injury.
Description
This project will investigate the fundamental mechanisms that allow the newborn brain to maintain stable blood flow, focusing on the role of the TrpC6 ion channel and how it is disrupted by chronic perinatal hypoxia. By identifying how hypoxia and associated epigenetic regulators like microRNA-210 impair cerebral autoregulation, this research aims to develop new therapeutic strategies to protect the developing brain in vulnerable infants and improve lifelong neurological outcomes.