Award
NIH Reporter #4R00AG075242-03
Synthetic Reconstruction of Human Chaperone Networks in Yeast Models of Neurodegeneration
Recipient
Temple University of the Commonwealth, Philadelphia, PA
Award Amount
$249,000.00
Ceiling
$249,000.00
Awarded
May 19, 2026
Identifier
4R00AG075242-03
NIH-funded project to map human chaperone networks in yeast models to identify therapeutic targets for neurodegenerative diseases.
Description
This project aims to build the first exhaustive map of a chaperone network against ADRD-associated proteins TDP43, FUS, and TAU. It leverages a new genetic technique to express and study all 12,155 possible combinations of the human Hsp40-Hsp70-Hsp110 network in yeast models of ADRD. The project will identify key chaperones as therapeutic targets for ADRD.