Award
National Institute of Environmental Health Sciences 1R01ES036522-01A1
Epigenetic Control of High Confidence Autism Spectrum Disorder Genes
Recipient
Henry Ford Health + Michigan State University Health Sciences
Award Amount
$790,980.00
Ceiling
$790,980.00
Awarded
April 01, 2026
Identifier
1R01ES036522-01A1
A research project funded by the National Institute of Environmental Health Sciences to study epigenetic and environmental influences on Autism Spectrum Disorder genes, focusing on CHD8 mutations and potential therapeutic interventions.
Description
This project focuses on understanding the epigenetic and environmental factors contributing to Autism Spectrum Disorder (ASD), with potential for developing targeted interventions. It aims to investigate the responses of human cerebral organoids derived from individuals with mutations in CHD8 and other ASD risk variants to environmental exposures, and to explore gene silencing and derepression strategies to rescue phenotypes associated with CHD8 insufficiency.