Award
National Institute on Aging 5R01AG075813-05
The interaction effects of genetic variants, age, diet, sex and mitochondrial copy number on Alzheimer's disease, aging-phenotypes and longevity
Recipient
University of Tennessee Health Science Center, Memphis, TN
Award Amount
$484,593.00
Ceiling
$484,593.00
Awarded
December 15, 2025
Identifier
5R01AG075813-05
A research project funded by the National Institute on Aging to study how genetic and environmental factors affect mitochondrial DNA copy number and its link to Alzheimer's disease and aging, using mouse models and human data integration.
Description
This project aims to understand the interaction between genetic variants, mitochondrial DNA copy number, diet, sex, and aging in relation to Alzheimer's disease and longevity. It involves extensive data collection, integration, and analysis across multiple tissues and phenotypes using mouse models and human GWAS data. The results will be shared openly and aim to develop models for potential interventions.