National Institute of Neurological Disorders and Stroke 11416823

Neural circuits regulating brain-wide effects of oxytocin neurons

This NIH-funded project by New York University School of Medicine studies how oxytocin neurons regulate brain-wide effects, focusing on their modulation and impact on social behavior and memory, comparing oxytocin with acetylcholine effects, and exploring sleep's role in social learning.

Description

The project aims to investigate the spatiotemporal modulation of oxytocin (OXT) in the central nervous system, focusing on its regulation by upstream brain regions and its effects on network computations in target areas. The study will measure signals from next-generation modulatory GRAB sensors, analyze fluctuations during waking behaviors and sleep, and explore the impact of OXT on social behavior and memory. It will compare the effects of OXT with acetylcholine (ACh) on hippocampal and neocortical network patterns, and examine how sleep patterns influence social learning.

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