Award
National Institute of Dental and Craniofacial Research 5R01DE031274-05
Impact of Saccharibacteria and their bacterial hosts in Periodontal and Inflammatory Diseases
Recipient
ADA FORSYTH INSTITUTE, INC.
Award Amount
$466,098.00
Ceiling
$466,098.00
Awarded
December 01, 2025
Identifier
5R01DE031274-05
NIH-funded research by ADA FORSYTH INSTITUTE, INC. studying the impact of Saccharibacteria and their bacterial hosts on periodontal and inflammatory diseases, aiming to understand their pathogenic mechanisms and interactions.
Description
This project investigates the role of Saccharibacteria (TM7) and their bacterial hosts in periodontal and inflammatory diseases. It focuses on pathogenic genes, interaction with host bacteria, and immunological behavior across species. The research aims to enhance understanding of TM7 bacteria and their role in disease through culturing diverse TM7 bacteria, gene regulation studies, and interaction assays.