Award
National Institute of Neurological Disorders and Stroke 5R33NS133257-03
OPC-X screen: Discovery of small molecule inhibitors to overcome extrinsic inhibition of remyelination.
Recipient
J. DAVID GLADSTONE INSTITUTES
Award Amount
$472,500.00
Ceiling
$472,500.00
Awarded
July 23, 2026
Identifier
5R33NS133257-03
Award for research on discovering small molecule inhibitors to promote remyelination in neuroinflammatory diseases, conducted by J. DAVID GLADSTONE INSTITUTES, funded by NIH.
Description
The project involves screening compounds to promote remyelination in neuroinflammatory diseases like Multiple Sclerosis. It aims to develop and optimize high-throughput screening assays for small molecule inhibitors, focusing on overcoming extrinsic inhibition factors such as fibrinogen, with in vivo validation in animal models. The research is conducted by J. DAVID GLADSTONE INSTITUTES in San Francisco, CA, funded by NIH grant PAR-21-124.