Award
National Cancer Institute 5R01CA270332-04
Investigating the Genesis of Tumor Immune Microenvironment (TIME) as a function of Inflammation
Recipient
University of California, San Francisco
Award Amount
$483,213.00
Ceiling
$483,213.00
Awarded
December 09, 2025
Identifier
5R01CA270332-04
This NIH grant funds research to study how inflammation affects the tumor immune microenvironment in breast cancer, using advanced analysis and bioinformatics to understand immune evasion mechanisms.
Description
The project focuses on understanding the immune cell infiltrate in breast cancer, particularly how inflammation influences the tumor immune microenvironment (TiME). It aims to elucidate mechanisms by which systemic inflammation, aging, obesity, stress, and viral infections contribute to the development of immunosuppressive, cold tumors. The study will utilize high-content analysis, deep learning, and bioinformatics to identify tumor subtypes and key events in tumor immune evasion.