Award
NIH Reporter #4R01CA279401-03
Investigating the Pathogenic Role of Tubulin Post-translational Modifications in CIPN
Recipient
Columbia University Health Sciences
Award Amount
$1,905,541.00
Ceiling
$1,905,541.00
Awarded
September 04, 2026
Identifier
4R01CA279401-03
NIH awarded a multiyear grant to Columbia University Health Sciences to study the role of tubulin modifications in chemotherapy-induced peripheral neuropathy, aiming to understand disease mechanisms and identify therapeutic targets.
Description
This NIH grant supports research on the mechanisms of chemotherapy-induced peripheral neuropathy (CIPN), focusing on tubulin post-translational modifications and neuronal dysfunction. The project aims to evaluate the role of delta-2 tubulin in axonal degeneration and examine mitochondrial and TRP channel dysfunction in neurons to develop cellular and preclinical models for CIPN mechanisms and potential therapeutic targets.