Award
National Institute of Allergy and Infectious Diseases 1R01AI192521-01A1
The role of GPR132 in regulating T cell responses in infection and cancer
Recipient
Rutgers Biomedical and Health Sciences
Award Amount
$647,356.00
Ceiling
$647,356.00
Awarded
June 17, 2026
Identifier
1R01AI192521-01A1
Research project investigating the role of GPR132 in regulating CD8 T cell responses during infection and cancer, aiming to understand its function and therapeutic potential.
Description
This project aims to determine the role of the G protein-coupled receptor GPR132 in the regulation of CD8 T cell responses during infection and tumorigenesis. It will uncover the temporal role of GPR132 in regulating T cell accumulation and function, examine the abundance of GPR132-activating ligands within tissue during health and disease, and determine how altering GPR132 ligand availability could modulate T cell responses. The research could lead to therapeutic strategies to enhance or inhibit T cell responses in the context of infection, cancer, or autoimmune disease.