Award
NIH Reporter #5R01DK139052-03
Skeletal Muscle Fibrosis and Progesterone Receptor
Recipient
Northwestern University, Chicago, IL
Award Amount
$657,971.00
Ceiling
$657,971.00
Awarded
April 27, 2026
Identifier
5R01DK139052-03
This award funds research to understand the role of progesterone receptor signaling in inguinal hernia formation, focusing on muscle fibrosis and atrophy, and to develop preventive and therapeutic strategies.
Description
The project investigates a novel mechanism underlying inguinal hernia formation linking progesterone hormone signaling with abdominal muscle fibrosis in a mouse model and human tissues. The study aims to test treatments that block progesterone action to prevent or reverse hernias.