Award
National Institute of General Medical Sciences 5R35GM127027-09
Mechanisms of Immune Dysfunction after Trauma and Surgical Sepsis
Recipient
UNIVERSITY OF PITTSBURGH AT PITTSBURGH
Award Amount
$697,185.00
Ceiling
$697,185.00
Awarded
May 22, 2026
Identifier
5R35GM127027-09
This NIH grant supports research on immune dysfunction after trauma and surgical sepsis, using multi-omics and single-cell genomics to identify biomarkers and therapeutic targets, with a focus on creating a Blood Atlas and online resources.
Description
Trauma and surgical sepsis are leading causes of morbidity and death worldwide, often resulting in immune dysfunction. This project aims to characterize immune responses using multi-omics approaches, develop a Blood Atlas, and identify biomarkers and therapeutic targets. The project involves advanced single-cell genomics, epigenetic analysis, and computational strategies. The project will compare results with studies in sepsis and develop online resources for the research community.