Award
National Institute of General Medical Sciences 1R35GM162083-01
Sex differences in regulation of innate immune response by neurotransmitters
Recipient
University of Miami School of Medicine
Award Amount
$383,750.00
Ceiling
$383,750.00
Awarded
February 27, 2026
Identifier
1R35GM162083-01
The award funds research on sex-specific regulation of innate immune responses by neurotransmitters, aiming to uncover molecular mechanisms and potential therapeutic targets related to sex differences in immune function.
Description
This project investigates sex differences in immune responses, focusing on how neurotransmitters GABA and glutamate regulate monocyte and neutrophil activity in a sex-dependent manner through epigenetic, transcriptional, and metabolic programming. The study aims to understand the contributions of sex hormones versus chromosomes in myeloid cell programming and the mechanisms underlying sex-specific immune responses, with implications for therapeutic strategies targeting innate immune dysregulation.