Award
NIH Reporter #1R01DK146932-01
The role of the neuronal entero-pancreatic circuit in glucose metabolism
Recipient
University of Miami School of Medicine, Coral Gables, FL
Award Amount
$537,250.00
Ceiling
$537,250.00
Awarded
June 03, 2026
Identifier
1R01DK146932-01
NIH-funded research project studying the neuronal entero-pancreatic circuit's role in glucose metabolism to understand gut influence on insulin secretion and blood glucose regulation using advanced genetic and imaging methods.
Description
This project investigates the role of the neuronal entero-pancreatic circuit in glucose metabolism, focusing on how gut signals influence insulin secretion and blood glucose regulation. The research aims to elucidate mechanisms coupling gut sensing to enteric neurons, neurotransmission from enteric neurons to pancreatic islet cells, and the overall impact on glucose metabolism. Advanced genetic and imaging technologies, including intravital imaging and single nuclei sequencing, will be employed.