Award
National Institute of Allergy and Infectious Diseases 5UG3AI190386-02
Mechanisms of Immediate Non-IgE-mediated Drug Hypersensitivity Reactions (MIND-HR)
Recipient
UT Southwestern Medical Center, Dallas, TX
Award Amount
$394,205.00
Ceiling
$394,205.00
Awarded
June 11, 2026
Identifier
5UG3AI190386-02
Research project funded by NIAID to investigate non-IgE-mediated drug hypersensitivity reactions, focusing on MRGPRX2 receptor involvement, to improve diagnostics and patient care.
Description
This project aims to study MRGPRX2 expression levels in sera and skin mast cells, and skin test responses to various ligands, to better understand hyperreactive phenotypes and develop diagnostic tools to prevent misclassification and unnecessary drug restrictions related to non-IgE-mediated drug hypersensitivity reactions.