Award
National Institute of Neurological Disorders and Stroke 5R01NS136342-02
Long distance regressive signaling underlies sculpting of the nervous system during development.
Recipient
Vanderbilt University, Nashville, TN, United States
Award Amount
$528,712.00
Ceiling
$528,712.00
Awarded
January 14, 2026
Identifier
5R01NS136342-02
Research on neuronal signaling mechanisms related to neurodegeneration and development, focusing on long-distance regressive signaling and its role in nervous system patterning and diseases like ALS and Alzheimer's.
Description
This project investigates the mechanisms of long-distance regressive signaling in neurons, focusing on the role of p75NTR receptor internalization, cleavage, palmitoylation, and their impact on neuronal development and neurodegeneration.