Award
NIH Reporter #1F31AI197582-01A1
Elucidating SPEN-Driven m6A Regulation During Henipavirus Infection
Recipient
Vanderbilt University
Award Amount
$35,582.00
Ceiling
$35,582.00
Awarded
August 14, 2026
Identifier
1F31AI197582-01A1
Research project to understand how henipaviruses manipulate m6A regulatory pathways to enhance infection, using biochemical, virological, and transcriptomic approaches, conducted at Vanderbilt University.
Description
This project aims to elucidate the molecular mechanisms of henipavirus pathogenesis, focusing on the role of SPEN family proteins in viral infection. Using Cedar virus as a surrogate, the research will identify host proteins interacting with viral RNA, assess m6A methylation changes, and evaluate the impact on viral transcript stability and translation. The findings could reveal new cellular targets for host-directed antivirals.