Award
National Institute of Allergy and Infectious Diseases 5R21AI182639-02
Investigating Plasmodium vaccination in 'dirty' mice
Recipient
HENNEPIN HEALTHCARE RESEARCH INSTITUTE, MINNEAPOLIS, MN, USA
Award Amount
$183,820.00
Ceiling
$183,820.00
Awarded
December 01, 2025
Identifier
5R21AI182639-02
A research grant awarded to study Plasmodium vaccine efficacy in mouse models that mimic human immune responses, focusing on microbiota influence and adjuvant testing to improve malaria vaccine outcomes.
Description
This project aims to evaluate the immunogenicity and efficacy of Plasmodium vaccines using a physiologically relevant small animal model that mimics human immune responses, particularly focusing on the role of microbiota and immune system changes. The study will test IL-15C as a vaccine adjuvant to enhance liver-resident memory T cell (Trm) formation and assess vaccine efficacy in different mouse models.