Award
National Institute of General Medical Sciences 1R01GM164517-01
Regulation of apical constriction by the RhoGEF protein Plekhg5
Recipient
University of Alabama at Birmingham
Award Amount
$445,358.00
Ceiling
$445,358.00
Awarded
May 26, 2026
Identifier
1R01GM164517-01
Research project funded by NIGMS to study the role of Plekhg5 in epithelial morphogenesis and apical constriction using Xenopus, including analysis of human genetic variants.
Description
This project investigates the molecular mechanisms of epithelial morphogenesis, focusing on apical constriction regulated by the RhoGEF protein Plekhg5. Using Xenopus as a model organism, the study aims to understand the sequential events involving Plekhg5 and Rho signaling in apical constriction and to analyze human PLEKHG5 variants for their effects on protein function. The research will provide insights into embryonic development and human disease mechanisms.