Award
National Institute of Allergy and Infectious Diseases 5R37AI195421-02
Therapeutic vaccination to boost autologous neutralizing antibodies for ART free HIV Control
Recipient
National Institute of Allergy and Infectious Diseases
Award Amount
$881,967.00
Ceiling
$881,967.00
Awarded
July 14, 2026
Identifier
5R37AI195421-02
Award for developing a personalized mRNA-LNP therapeutic vaccine to boost neutralizing antibodies for ART-free HIV remission, including experimental and mechanistic studies.
Description
This project involves developing a personalized mRNA-LNP therapeutic vaccine strategy to enhance autologous neutralizing antibody responses in people with HIV, aiming for ART-free remission. The project includes a rhesus macaque experiment with various vaccination regimens and mechanistic studies to evaluate post-ART virus control and antibody responses.