Award
NIH Reporter #5R21AI181039-02
Mechanisms by which ICP3 Overcomes Vibrio cholerae Phage Defenses
Recipient
Tufts University Boston
Award Amount
$202,350.00
Ceiling
$202,350.00
Awarded
May 14, 2025
Identifier
5R21AI181039-02
The award supports research on how the ICP3 phage overcomes bacterial defenses in Vibrio cholerae, with potential implications for cholera treatment or prevention.
Description
This project aims to explore the genetic requirements of ICP3 for circumventing phage defense systems of Vibrio cholerae. ICP3 is a virulent phage that preys on Vibrio cholerae within the human small intestine, and resistance to it is rarely observed. The project will delete accessory genes of ICP3 to study their roles in evading bacterial defenses.