Award
NIH Reporter #5K08DK132511-04
Structural regulation of megalin recycling in the proximal tubule
Recipient
Columbia University Health Sciences, New York, NY
Award Amount
$166,644.00
Ceiling
$166,644.00
Awarded
July 22, 2026
Identifier
5K08DK132511-04
A 5-year NIH K08 Career Development award to study the structural regulation of megalin recycling in kidney proximal tubules using cryo-EM and mass spectrometry, aiming to enable new treatments for proteinuric diseases.
Description
This K08 Career Development Proposal details the candidate’s research on the structural regulation of megalin recycling in the kidney proximal tubule (PT) that will be conducted during a 5-year mentored award period. The research involves cryo-electron microscopy and mass spectrometry to understand structural mechanisms of megalin recycling, aiming to develop treatments for proteinuric disease.