Award
National Heart, Lung, and Blood Institute 1R03HL187206-01
Contribution of complement activation to JAK2V617F myeloproliferative neoplasm thrombosis
Recipient
University of Minnesota, Minneapolis, MN, United States
Award Amount
$231,000.00
Ceiling
$231,000.00
Awarded
August 04, 2026
Identifier
1R03HL187206-01
NIH funded research project to study the role of complement activation in thrombosis among patients with JAK2V617F+ myeloproliferative neoplasms, aiming to understand mechanisms and test complement inhibition as a therapeutic approach.
Description
This NIH grant project aims to define how complement activation contributes to thrombosis in patients with JAK2V617F+ myeloproliferative neoplasms (MPNs). The research will investigate the role of complement signaling in promoting vascular inflammation and thrombosis, using patient serum, plasma, and innovative human and animal models to evaluate complement regulatory proteins and the effect of anti-complement antibodies on vascular occlusion and thrombosis.