Award
National Institute on Aging RFA-RM-21-017
A smart cell drug (SmaCD) delivery platform for mobile, targetable, and self-regulated combination therapy: a model project to rescue antibodies from Alzheimer's disease (AD) clinical trial failures
Recipient
Buck Institute for Research on Aging
Award Amount
$914,477.00
Ceiling
$914,477.00
Awarded
July 28, 2025
Identifier
RFA-RM-21-017
This NIH-funded project aims to develop a smart cell drug delivery platform for Alzheimer's disease, supporting combination therapies and targeting affected brain regions, with a total award amount of $914,477 over nearly five years.
Description
The project focuses on developing a smart cell-based drug delivery system for Alzheimer's disease. It involves in vitro and in vivo validation, targeting brain regions affected by AD, and aims to support combination therapy with drugs like Aducanumab and Zagotenemab. The project emphasizes translational research and innovative drug delivery methods.