Award
National Institute of Allergy and Infectious Diseases 5R21AI182709-02
Structural, functional, and microbiological exploration toward synergistic dual aminoglycoside combinations
Recipient
University of Illinois at Chicago
Award Amount
$197,436.00
Ceiling
$197,436.00
Awarded
March 30, 2026
Identifier
5R21AI182709-02
The award supports research on dual-aminoglycoside antibiotic combinations to combat multidrug-resistant bacteria by studying their structural and functional mechanisms and developing improved therapeutics.
Description
This project aims to explore dual-aminoglycoside combinations that bind separate sites on the bacterial ribosome, which have shown synergistic bactericidal activity against multidrug-resistant bacteria. The research includes structural studies of ribosome-aminoglycoside complexes, assessment of synergy and resistance suppression, and development of next-generation aminoglycosides.