Award
NIH Reporter #5F31AI191695-02
Separating the molecular determinants that govern the evolution of Orthoflavivirus NS5-mediated IFN antagonism
Recipient
ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY
Award Amount
$49,114.00
Ceiling
$49,114.00
Awarded
June 12, 2026
Identifier
5F31AI191695-02
Research project to study the molecular mechanisms of flavivirus NS5 protein in interferon antagonism to inform drug and vaccine development.
Description
This project aims to investigate the structural and functional determinants that govern flaviviruses' ability to utilize various modes of non-structural protein 5 (NS5)-mediated interferon (IFN) antagonism and their evolution. The research will provide insights into potential drug targets, vaccine strategies, and the evolutionary potential of emerging flaviviruses.