Award
National Institute of General Medical Sciences 5R35GM145244-05
Homolog pairing in meiosis
Recipient
University of California at Davis
Award Amount
$453,014.00
Ceiling
$453,014.00
Awarded
May 14, 2026
Identifier
5R35GM145244-05
This NIH-funded project investigates chromosome organization during meiosis to understand causes of birth defects and spontaneous abortions, using yeast and zebrafish models.
Description
The project aims to understand how chromosome organization in the nucleus contributes to correct pairing, synapsis, and recombination during meiosis I prophase, and how errors in these processes lead to abnormalities. The research uses model organisms, budding yeast and zebrafish, to study the 3D configuration of chromosomes and the mechanisms of homolog pairing.