Award
National Institute on Aging 5R01AG081419-04
Role of the microglial immune-oxysterol 25-hydroxycholesterol in mediating neuroinflammation and neurodegeneration in the P301S tau transgenic mouse model of Alzheimer's disease
Recipient
Washington University, Saint Louis, MO, United States
Award Amount
$445,870.00
Ceiling
$445,870.00
Awarded
March 20, 2026
Identifier
5R01AG081419-04
The award funds research on how the microglial immune-oxysterol 25-hydroxycholesterol contributes to neuroinflammation and neurodegeneration in Alzheimer's disease, using a transgenic mouse model. The study focuses on the role of 25HC in tau pathology and cholesterol metabolism, aiming to identify therapeutic targets.
Description
This project investigates the role of 25-hydroxycholesterol synthesized by microglia in mediating neuroinflammation and neurodegeneration in Alzheimer's disease using the P301S tau transgenic mouse model. The research aims to understand the mechanisms by which 25HC influences tau-dependent neuroinflammation and neurodegeneration and to develop novel therapeutic strategies for Alzheimer's disease and related dementias.