Award
National Institute of Allergy and Infectious Diseases 5R01AI181779-03
Mechanisms regulating fetal membrane and neutrophil responses to infection
Recipient
Yale University
Award Amount
$703,356.00
Ceiling
$703,356.00
Awarded
February 13, 2026
Identifier
5R01AI181779-03
A research grant awarded to study inflammatory mechanisms in fetal membranes and neutrophils related to infection, with implications for preventing preterm birth.
Description
This project aims to understand how Toll-like receptor 8-activating microRNAs mediate fetal membrane inflammation and maternal neutrophil activation in response to bacterial triggers. The study will explore the role of exosomes carrying microRNAs in delivering inflammatory signals, potentially leading to new predictors and therapeutic targets for pregnancy complications.