Award
NIH Reporter #5R35GM141891-05
Mechanistic Pharmacodynamic Modeling for Drug Combination Responses
Recipient
Clemson University, Clemson, SC, United States
Award Amount
$372,303.00
Ceiling
$372,303.00
Awarded
June 05, 2025
Identifier
5R35GM141891-05
This award funds research to develop mechanistic pharmacodynamic models to predict drug combination responses, integrating network biology, experimental validation, and genetic screening to improve precision medicine and drug development.
Description
The project aims to improve simulation models for predicting patient responses to drugs and drug combinations by integrating innovative theory, computation, and experimental approaches focusing on proliferation and death of single cells. It involves developing mechanistic pharmacodynamic models, high-dimensional genetic interaction screening using MuSIC multiplexing, and modeling across multiple cell lines with multi-omic data to enhance drug response predictions.