Award
NIH Reporter #5P01CA265794-04
Core 2: Mammalian Artificial Chromosome (MAC)
Recipient
University of Pennsylvania, Philadelphia, PA, United States
Award Amount
$365,276.00
Ceiling
$365,276.00
Awarded
April 21, 2026
Identifier
5P01CA265794-04
Award to University of Pennsylvania for research on mammalian artificial chromosomes to study cancer biology, focusing on DNA damage and chromosome segregation errors, with an award amount of $365,276 funded by the National Cancer Institute.
Description
The project aims to support research in cancer biology focusing on the downstream consequences of DNA damage, chromosome missegregation during cell division, and related mechanisms in tumors. The core will develop and employ mammalian artificial chromosomes (MACs) as tools for genetic manipulation, studying chromosome segregation errors, and developing biomarkers for patient response. MACs can carry large genetic payloads and exist independently in cells, providing a non-disruptive method for genetic studies.