Award
NIH Reporter #3R01AG076786-05S1
Efferocytosis by Bone Marrow Stromal Cells and Bone Aging
Recipient
University of Rochester, Rochester, NY
Award Amount
$11,060.00
Ceiling
$11,060.00
Awarded
March 04, 2026
Identifier
3R01AG076786-05S1
The project investigates how efferocytosis by mesenchymal stromal cells impacts their function and bone maintenance, exploring mechanisms that contribute to bone loss in aging and potential therapeutic strategies.
Description
This project addresses a novel mechanism of mesenchymal lineage dysfunction and bone loss in aging. It aims to elucidate mechanisms connecting phagocytic activity of mesenchymal stromal cells, metabolic disruption, senescence, and their dysfunction leading to decreased osteogenic capacity and bone loss, which is highly relevant to reducing the burdens of human aging and disability.