# NIH Reporter #5F31AG091981-02

Genetic and Environmental Sources of Heterogeneity in Alzheimer's Disease: A Pathway Specific Approach

**Recipient:** University of Pennsylvania

**Award Amount:** $50,114.00
**Ceiling:** $50,114.00

**Awarded:** August 28, 2026

**Identifier:** 5F31AG091981-02

The project will study genetic and environmental sources of heterogeneity in Alzheimer's disease by developing and comparing pathway-specific polygenic risk scores and assessing how their effects vary with fine particulate matter exposure.

### Description

Project to explore methods for constructing pathway-specific polygenic risk scores and investigate interactions between pathway-specific genetic risk factors and fine particulate matter exposure in relation to dementia risk.

[View original record](https://reporter.nih.gov/search/J7l2tQ4hHkqRePwGq3m5kA/project-details/11469764)