Award
National Institute of Biomedical Imaging and Bioengineering 5R01EB034573-04
Engineering the biology of AAV secretion and production
Recipient
Duke University, Durham, NC, United States
Award Amount
$491,773.00
Ceiling
$491,773.00
Awarded
May 12, 2026
Identifier
5R01EB034573-04
This NIH-funded project aims to improve gene therapy vector production by studying and engineering the MAAP protein to enhance AAV secretion and exosome production, addressing manufacturing challenges in recombinant AAV vectors.
Description
Research project focused on defining the molecular mechanisms by which MAAP enhances AAV secretion and exosome production, and engineering novel MAAP proteins to improve functionalities for better AAV vector production and exosome delivery technology.