Award
NIH Reporter #11331966
Exploiting Carbon Monoxide Biofoams to Radio-Sensitize Rectal Cancer Cells While Protecting Normal Bowel
Recipient
University of Iowa
Award Amount
$251,820.00
Ceiling
$251,820.00
Awarded
May 12, 2026
Identifier
11331966
A research project funded by the National Cancer Institute to develop and evaluate carbon monoxide biofoams to enhance radiotherapy effectiveness in rectal cancer while protecting normal bowel tissue, with an award amount of approximately $251,820 for FY 2026.
Description
The project involves evaluating novel CO biofoams as an adjunctive strategy to chemoradiotherapy for rectal cancer, focusing on mechanisms of protection in tumors and normal tissue. The project aims to improve response to neoadjuvant therapy and reduce surgical requirements for rectal cancer patients. It includes developing GI formulations for CO delivery and evaluating effects on tissue responses and oxidative damage.