Award
National Institute of General Medical Sciences 5R35GM128855-09
Spindle Assembly Checkpoint Silencing
Recipient
University of North Carolina Chapel Hill
Award Amount
$454,118.00
Ceiling
$454,118.00
Awarded
July 24, 2026
Identifier
5R35GM128855-09
Research project funded by the National Institute of General Medical Sciences to study the regulation of APC/C during mitosis and its implications in cell cycle control and cancer.
Description
The project focuses on understanding the regulation of the Anaphase-Promoting Complex/Cyclosome (APC/C) during mitosis, particularly its role in cell cycle control and its dysregulation in cancer. The research aims to elucidate the conformational changes and molecular mechanisms involved in APC/C function, using techniques such as cryo-EM and mass photometry.