Award
NIH Reporter #1R01AI201785-01
Decoding the specificity of human T cell allorecognition
Recipient
University of Notre Dame
Award Amount
$856,216.00
Ceiling
$856,216.00
Awarded
August 20, 2026
Identifier
1R01AI201785-01
Research project funded by NIAID to study the biology and specificity of human T cell allorecognition related to transplant rejection, aiming to improve prediction, monitoring, and treatment of acute cellular rejection.
Description
This project aims to study the immunological underpinnings and detailed biology of alloreactivity and acute cellular rejection (ACR) of transplanted tissues and organs. The research will focus on understanding the specificity and biology of CD8+ T cells driving ACR, including their structural and biochemical features, TCR affinity, and environmental niches.