NIH Reporter #1R56DA067015-01

Mechanisms and Medical Countermeasures for Ultra-Potent Synthetic Opioid Overdose

Research project to understand toxicity mechanisms of ultra-potent synthetic opioids such as fentanyl and nitazenes and develop effective countermeasures to reduce overdose deaths and improve emergency response.

Description

This project aims to identify the physiological mechanisms that make ultra-potent synthetic opioids lethal and to test new strategies to reverse their effects when standard treatments like naloxone fail. The findings will inform improved overdose countermeasures, emergency responses, and preparedness for chemical threat scenarios involving synthetic opioids.

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