Award
NIH Reporter #5R01AR081228-05
To explore the molecular and cellular effects of transient DUX4 expression in skeletal muscle
Recipient
University of Minnesota
Award Amount
$323,950.00
Ceiling
$323,950.00
Awarded
August 14, 2026
Identifier
5R01AR081228-05
This NIH-funded project studies the long-term effects of transient DUX4 expression in skeletal muscle to understand its role in facioscapulohumeral muscular dystrophy (FSHD) pathology, using a mouse model to explore muscle abnormalities and cellular changes.
Description
The project aims to understand the molecular and cellular effects of transient DUX4 expression in skeletal muscle, which is relevant to facioscapulohumeral muscular dystrophy (FSHD). It investigates whether transient DUX4 expression can trigger degenerative processes or set up a pro-degenerative state that contributes to muscle pathology.