Award
National Institute of General Medical Sciences 5R35GM144076-05
Small-molecule signals controlling nematode development
Recipient
Rebecca A. Butcher
Award Amount
$381,250.00
Ceiling
$381,250.00
Awarded
December 18, 2025
Identifier
5R35GM144076-05
Research project funded by NIGMS to study small-molecule signals controlling nematode development, aiming to understand biosynthetic pathways and signaling mechanisms with potential applications in controlling parasitic infections.
Description
This project investigates small-molecule signals that control nematode development, focusing on the biosynthesis, mechanisms, and biological roles of key signaling molecules such as ascarosides, nacq#1, and nemamides in Caenorhabditis elegans. The research aims to map biosynthetic pathways, identify signaling molecules, and understand how these pathways intersect with other metabolic processes, with implications for parasitic nematodes.