Award
National Eye Institute 1R21EY036176-01A1
Amplified femtosecond laser permeabilization and poration for nonviral corneal gene delivery
Recipient
University of California-Irvine
Award Amount
$431,750.00
Ceiling
$431,750.00
Awarded
April 28, 2025
Identifier
1R21EY036176-01A1
This award supports research to develop a laser-based, nonviral gene delivery method for the cornea, using femtosecond laser pulses to create microchannels and pores for plasmid DNA transport, aiming for safer and more efficient gene therapy.
Description
The project aims to develop a non-invasive, transepithelial gene delivery system for the cornea using femtosecond laser technology to create microchannels and open membrane pores, facilitating plasmid DNA delivery without the need for viral vectors.