NIH Reporter #11399702

Evaluating the protein homeostasis of N-methyl-D-aspartate receptors containing pathogenic GluN2B subunits

Research project awarded to study the protein homeostasis of NMDA receptors with pathogenic GluN2B subunits to identify therapeutic targets for neurological disorders.

Description

The project focuses on the molecular mechanisms of NMDA receptor folding, assembly, trafficking, and degradation, especially related to disease-associated variants. The study involves biochemical and molecular techniques, including studies on cortical neurons derived from human induced pluripotent stem cells. The goal is to identify therapeutic targets for disorders such as GRIN diseases, schizophrenia, autism spectrum disorder, and Alzheimer’s disease.

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