Award
NIH Reporter #5R01GM102262-12
LIM domain kinases: regulation and substrate recognition
Recipient
Yale University, New Haven, CT, United States
Award Amount
$351,750.00
Ceiling
$351,750.00
Awarded
August 08, 2025
Identifier
5R01GM102262-12
This award supports research on LIM domain kinases, investigating their regulation, substrate recognition, and activation mechanisms using structural biology methods.
Description
The project focuses on the regulation and substrate recognition of LIM domain kinases. It aims to understand the structural basis of kinase autoregulation and substrate specificity. The study involves structural biology techniques such as X-ray crystallography and molecular dynamics. It also investigates the activation mechanisms of MRCK kinases downstream of CDC42.