Award
NIH Reporter #1R01AI183372-01A1
The role of an unusual variant nucleosome in Toxoplasma gondii life cycle
Recipient
INSTITUTE/RESEARCH/BIOTECHNOLOGY FDN
Award Amount
$133,693.00
Ceiling
$133,693.00
Awarded
August 25, 2025
Identifier
1R01AI183372-01A1
Research project funded by NIAID to study the role of a unique nucleosome in gene expression regulation in Toxoplasma gondii, aiming to understand epigenetic mechanisms and identify potential drug targets.
Description
The project investigates how a unique nucleosome contributes to gene expression regulation in Toxoplasma gondii, focusing on epigenetic mechanisms and potential drug targets. It explores the role of a double-variant nucleosome (DVN) composed of histones H2A.Z and H2B.Z, and how its acetylation acts as a sensor for metabolic changes, influencing gene expression and parasite adaptation.